Ep. 44 Testosterone Replacement Therapy: An Evolutionary Lens

Testosterone Replacement Therapy is gaining popularity with many advocates and detractors. Lucas and Brion explore the evolutionary basis for testosterone and how that can inform your choice on whether to get on TRT

Notes:

Testosterone prescribing in the United States, 2002-2016: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396809/

Danish Study on Lowering T levels: https://academic.oup.com/jcem/article/92/12/4696/2597312#52560365

The He Hormone, 2000 New York Times: https://www.nytimes.com/2000/04/02/magazine/the-he-hormone.html

Testicle Shrinkage: https://www.thebodywellusa.com/will-taking-testosterone-make-testicles-shrink/

Testosterone Therapy and anabolic steroids: https://thinksteroids.com/steroid-profiles/testosterone/

TRT shuts down production of Pregnenolone and other upstream metabolites: https://www.sciencedirect.com/science/article/pii/0022473185902572?via%3Dihub

Supplementing Pregnenolone: https://www.testosteronewisdom.com/pregnenolone-what-you-need-to-know-about-this-precursor-hormone/

Forum thread on suppression: https://www.excelmale.com/forum/threads/anabolic-steroids-and-trt-decrease-shbg-dhea-pregnenolone-and-progesterone-in-men.3990/

T Trials showing Plaque Build Up: https://www.npr.org/sections/health-shots/2017/02/21/515456194/does-testosterone-improve-older-mens-health-it-depends

Evolutionary Psychology Wiki: https://en.wikipedia.org/wiki/Evolutionary_psychology

More Boy Children After War: https://www.popsci.com/scitech/article/2008-12/why-does-war-breed-more-boys/

Ghengis Kahn’s 16 Million Children: https://www.thevintagenews.com/2018/06/09/genghis-khan/

NY Times Is There Anything Good about Men: https://tierneylab.blogs.nytimes.com/2007/08/20/is-there-anything-good-about-men-and-other-tricky-questions/

Low Free Testosterone Predicts Mortality from Cardiovascular Disease: https://academic.oup.com/jcem/article/97/1/179/2833341

Benefits and Risks of TRT: https://www.excelmale.com/trt-benefits-vs-risks/

The Testosterone Scam the Kills Healthy Men: https://www.healthscamsexposed.com/2014/03/the-testosterone-scam-that-kills-healthy-men/

Testosterone linked to shorter male lifespan: https://www.news.com.au/lifestyle/health/testosterone-linked-to-shorter-male-lifespan/news-story/539c29145e7b98692c176e182ee4f777

Testosterone Levels Drop after having kids: https://www.medicalnewstoday.com/articles/234266.php#1

Low Testosterone and Suicide: https://www.ncbi.nlm.nih.gov/pubmed/23893672

Lower Testosterone causing suicide?: https://www.1st-man.com/low-testosterone-male-suicide/

Silent Epidemic of Male Suicide: https://www.bcmj.org/articles/silent-epidemic-male-suicide

Music by Jenny Jahlee from Live at KBOO

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